Colts vs. 49ers prediction, odds, spread: 'Monday Night Football' picks from 10,000 simulations
- Posted on December 22, 2025
- By CBS Sports
- 3 Views
Colts vs. 49ers prediction, odds, spread: 'Monday Night Football' picks from 10,000 simulations
SportsLine's model simulated Indianapolis vs. San Francisco 10,000 times and reveals its NFL picks today
