Cannabinoid Hyperemesis Syndrome (CHS) represents a paradoxical condition where regular cannabis users experience severe, cyclic vomiting despite the drug's well-known anti-nausea properties. This complex medical phenomenon occurs in chronic consumers and involves dysregulation of the endocannabinoid system. Understanding the mechanisms behind CHS is crucial for healthcare providers and patients, as cessation remains the most effective treatment while symptom management requires proper medical intervention and patient education.

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