San Francisco 49ers face a significant setback as star defensive end Nick Bosa deals with a calf strain sustained during recent competition. The All-Pro pass rusher is projected to miss multiple weeks of action, creating a notable gap in the team's defensive line. This injury comes at a critical juncture of the season, forcing the 49ers coaching staff to adjust their defensive strategies and rely on backup pass rushers to maintain their defensive unit's effectiveness during Bosa's recovery period.

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